Natural product synthesis

Research projects within Pospisil2ab focus on the (semi) synthetic preparation of natural substances, and on the development of new environmentally friendly synthetic procedures suitable for their preparation. In the field of natural substances, we focus mainly on (1) phenylpropanoid based plant secondary metabolites – lignans and neolignans, and on (2) plant growth regulators – gibberellins. This type of substances are prepared by (3) new synthetic procedures that are based on new synthetic methods and (pluripotent) reagents designed and developed within the group. The goal of such protocols is to create new structurally and stereo diverse chemical libraries of (potentially) biologically active substances. Substances that are subsequently used in the study of (bio)chemical transformations. The aim of the research is to find new molecular targets in studied biological targets. Our bioactivity studies focus mainly on substances with leishmanicidal and anthelmitic effects. (more info at www.pospisilab.com)