Bioactive Heterocyclic Derivatives

The group led by Lucie Plíhalová is dedicated to the design, preparation and research of new small heterocyclic, especially purine, molecules, most often derived from plant regulators. These substances have, in miniature concentrations, an unprecedented biological activity in plants, which can be better mapped by using their fluorescent or isotopically labelled derivatives. Controlled derivatization or slight modification of these plant molecules can also effectively modulate the biological effects on plant cells and tissues and thus prepare, for example, modern substances for the treatment of plants without significant burden on the environment. Inspired by plant substances, new heterocyclic bioactive substances with an effect on human cells and tissues, with potential use in cosmetics or hygiene, are also being prepared and investigated.